Team
Principal Investigator
Xiao-Ou Zhang PI
zhangxiaoou@tongji.edu.cn kepbod.com @kepbod 1239 Siping Road, Shanghai 200092
Xiao-Ou earned a B.E. in Biological Engineering from Huazhong Agricultural University and a B.S. in Computer Science from Huazhong University of Science and Technology in 2011. He received his Ph.D. in Computational Biology in 2016 from the CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences. During his doctoral studies he focused on the biogenesis and processing of long noncoding RNAs with distinctive structures, working with Prof. Li Yang and Prof. Ling-Ling Chen. In 2016 he moved to UMass Chan Medical School as a postdoctoral fellow in the lab of Prof. Zhiping Weng, where he developed computational methods to study how repetitive sequences function in gene regulation. He joined the School of Life Sciences and Technology at Tongji University in 2020 as a professor and group leader. His research focuses on developing computational algorithms and mining large-scale high-throughput data to investigate gene regulation driven by noncoding sequences.
Team Members
Zhongren Hu
PhD Student 2011399@tongji.edu.cnZhongren earned his B.S. in Bioinformatics from Tongji University in 2020 and joined Professor Zhang’s lab as a doctoral student the same year. His research focuses on developing computational methods to detect transposition events from long-read sequencing data.
Bo Xu
PhD Candidate 1194189468@qq.comBo received his B.S. in Bioinformatics from Tongji University in 2020 and is now a Ph.D. candidate in Biology there, expected to graduate in 2026. He profiles transposon insertions in both human and fly, and studies the conservation of piRNA clusters over mammalian evolution. Ultimately, he aims to understand how piRNA clusters silence transposon insertions and regulate gene expression.
Hanxi Shi
PhD Student 2111266@tongji.edu.cnHanxi earned her B.S. in Biology from Tongji University in 2021 and joined Professor Zhang’s lab to pursue her Ph.D. Her research focuses on the mechanisms by which transposable elements (TEs) contribute to the regulation of gene expression.
Ruofan Huang
PhD Student ruofanhuang@tongji.edu.cnRuofan received her B.E. in Biological Engineering from Beijing University of Chemical Technology in 2021 and began her Ph.D. with Professor Zhang at Tongji University the same year. She studies the biogenesis, processing and gene regulation of small noncoding RNAs, with a particular interest in how noncoding sequences contribute to human health and disease.
Lingfeng Xu
PhD Student 2311465@tongji.edu.cnI studied bioinformatics as an undergraduate at Tongji University, where I carried out a preliminary study of circular RNAs. I am now a graduate student in Professor Xiao-Ou Zhang’s lab, working with single-cell sequencing data. I am deeply interested in biology and machine learning, and I am always happy to discuss ideas.
Mengyao Cui
PhD Student 2311459@tongji.edu.cnMengyao received her B.S. in Applied Statistics from Northeastern University in 2023 and joined Professor Zhang’s lab for her Ph.D. She is drawn to research that brings mathematics and biology together, and hopes to make a meaningful contribution in that space.
Jing Yan
PhD Student 2333161@tongji.edu.cnJing graduated from Huazhong Agricultural University in 2023 with a B.S. in Bioinformatics and joined Professor Zhang’s lab to pursue a Ph.D. degree. She is drawn to unexplored questions in biology and to developing innovative approaches to difficult problems, and she continues to broaden her research skills in pursuit of her scientific goals.
Yubo Liu
PhD Student 2433326@tongji.edu.cnI graduated from Tongji University in 2024 with a B.S. in Bioinformatics and then joined Professor Xiao-Ou Zhang’s team. My work focuses on quantifying transposons at the single-cell level and on developing algorithms for that purpose. I am always glad to exchange ideas.
Siyu Xu
Master's Student syxu0912@tongji.edu.cnSiyu received her B.S. in Bioinformatics from Soochow University in 2024 and is pursuing her Master’s degree in Biology with Professor Xiao-Ou Zhang at Tongji University. She uses scRNA-seq data to identify transcription start sites (TSSs) and to explore their role in cellular phenotypes and regulatory programs. She hopes to deepen our understanding of transcriptional regulation and to open new approaches to related diseases.
Junru Wang
PhD Student 2511592@tongji.edu.cnJunru earned her B.S. in Bioinformatics from Tongji University in 2025 and joined the lab to pursue her Ph.D. Her research centers on circular RNAs and single-cell sequencing, and she aims to address practical biological questions through algorithm development and data analysis.
Yue Shi
Master's Student 2533126@tongji.edu.cnYue received his B.S. in Bioinformatics from Harbin Medical University in 2025 and is now pursuing a Master’s degree in Biology with Professor Xiao-Ou Zhang at Tongji University. His current work focuses on transcription start sites (TSSs) and their regulatory impact.
| Xiaobing Gu | Master's student (2021-2024) |
| Mingdong Wang | Master's student (2022-2025) |